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Additional info for Biological Activities of Steroids in Relation to Cancer. Proceedings of a Conference Sponsored by the Cancer Chemotherapy National Service Center, National Cancer Institute, National Institutes of Health, U. S. Department of Health, Education and Welfare
Many of the steroids studied by Segaloff and co-workers, as discussed above, are known to have anabolic effects. The compounds noted by Huggins and Mainzer (58) to decrease fibroadenoma growth in rats were also anabolic, as judged by the weight gain of the animals. Additional data on relative myotropic potency, as determined by the levator ani method, are given in Table I X . Further, the metabolic effects of 2-methyldihydrotestosterone have been observed in one patient and are reported to be qualitatively similar to those of testosterone ( 5 ) .
Cancer Chemotherapy National Service Center data. 0 36 VICTOR A. DRILL remissions (Table V I I I ) . 2-Methyldihydrotestosterone also increases ketosteroid output ( 5 ) . In general, 17-alkylated steroids do not increase 17ketosteroid excretion. A number of investigators have also suggested that the metabolism of testosterone to an estrogen may explain the exacerbation occasionally noted during androgen therapy. I t has since been shown that estrogens can be isolated from the urine of ovariectomized, adrenalectomized patients receiving androgens (86).
F. / . Am. Chem. Soc. 8 1 , in press (1960). Edwards, J. , Ringold, H. , and Djerassi, C. Troc. Chem. Soc. p. 87 (1959). , and Borman, A. Vitamins and Hormones 16, 303 ( 1 9 5 8 ) . Fried, J. , Kessler, W . , and Sabo, E. F. / . Am. Chem. Soc. 80, 2338 ( 1 9 5 8 ) . , and Sabo, E. F. J. Am. Chem. Soc. 76, 1455 ( 1 9 5 4 ) . , and Sabo, E. F. / . Am. Chem. Soc. in press. , Thoma, R. , and Klingsberg, A. J. Am. Chem. Soc. 75, 5764 (1953). Gabbard, R. , and Jensen, Ε. V. / . Org. Chem. 23, 1406 (1958).